L-arginine and caffeine

L-arginine and caffeine

I asked ChatGPT the following question:

I experience severe discomfort without any specific diagnosed diseases or injuries. When I take 6g of arginine jelly and a 200mg caffeine caplet, I feel completely fine after about 30 minutes. Does this make sense, or could it just be a placebo effect?

ChatGPT’s answer is:

This reaction can indeed make sense, as both L-arginine and caffeine can have physiological effects that might temporarily alleviate feelings of discomfort or low energy.

  1. L-arginine Effects: Arginine is an amino acid that helps increase nitric oxide production, which can improve blood flow and enhance oxygen delivery to tissues. This process can lead to feelings of improved energy or reduced fatigue, which may contribute to your overall sense of relief.
  2. Caffeine Effects: Caffeine is a central nervous system stimulant that can improve alertness, reduce perceived fatigue, and elevate mood temporarily. The 200mg dose is considered moderate and can boost energy levels, often providing relief if discomfort is related to low energy or mental fog.
  3. Placebo Factor: While these effects are likely real and based on the substances’ mechanisms, the placebo effect could still play a role, especially if your body has come to expect relief from this combination. The mere anticipation of feeling better can amplify the effects, making the combination feel even more effective.

In summary, it’s plausible that both physiological effects and placebo may be contributing to the relief you experience.

Bayer-Microsoft collaboration for agriculture

Bayer-Microsoft collaboration for agriculture

[기사 01]의 도입부의 내용을 보고 궁금하여 [자료 01], [자료 02], [자료 03]을 확인


[기사 01] 2024-09-21

Microsoft: Wie der Tech-Konzern so mächtig wurde – und noch mächtiger wird

https://www.spiegel.de/netzwelt/gadgets/microsoft-wie-der-tech-konzern-so-maechtig-wurde-und-noch-maechtiger-wird-a-9f3e2cf3-be66-42d5-965b-bd9ccc97bb65


[자료 01] 2023-11-13

Bayer collaboration with Microsoft connects farm data to address lack of data interoperability in agriculture

https://www.bayer.com/media/en-us/bayer-collaboration-with-microsoft-connects-farm-data-to-address-lack-of-data-interoperability-in-agriculture/

New connectors allow secure, compliant data exchange / Industry platform Microsoft Azure Data Manager expands as more companies bring solutions: Leaf Agriculture further enhances useability of farm machinery data and OneSoil powers in-season detection and identification of key cash crops / Bayer experts are available from November 12-18 in hall 8, booth C15

Bayer and Microsoft have announced new data connectors that enable secure and compliant data exchange between Bayer’s digital farming platform, Climate FieldView™, and original equipment manufacturers (OEMs) via Microsoft’s Azure Data Manager for Agriculture. This collaboration aims to address the longstanding issue of data interoperability in agriculture, allowing farmers to seamlessly integrate and utilize data from various sources. By enhancing connectivity, the partnership seeks to improve decision-making processes, promote sustainable practices, and drive innovation across the agricultural value chain.


[자료 02] 2024-08-08

AI in the fields: Copilot powers smarter farming

https://www.microsoft.com/en-us/industry/blog/sustainability/2024/08/08/ai-in-the-fields-copilot-powers-smarter-farming/

  • Microsoft is focusing on empowering around 600 million smallholder farmers globally by offering access to essential technology solutions.
  • Through Azure Data Manager for Agriculture and generative AI, Microsoft aims to help farmers implement smarter, sustainable farming practices.
  • The article highlights key challenges farmers face:
    • Yield losses can reach up to 40% due to pests and diseases.
    • Limited access to critical information and agronomic expertise, as seen in India, where agriculture employs over 43% of the workforce.
  • Microsoft collaborates with partners like ITC (an Indian multi-business company) to develop Krishi Mitra (“farming friend”):
    • An agricultural super app based on Microsoft’s copilot template.
    • Allows farmers to ask questions in their native languages, with AI-powered responses on weather, agronomy, and other key topics.
  • The app integrates natural language chat functionality with generative AI to provide tailored guidance on:
    • Crop management
    • Pest control
    • Soil health
    • Water conservation
  • Microsoft’s language localization tools ensure the app serves a linguistically diverse user base, giving farmers critical farming information in their preferred languages.
  • Expansion Goals:
    • By the end of 2024: Reach over 100,000 farmers in India.
    • By 2030: Aim for a 10 million user base, enhancing agricultural decision-making and sustainable practices.

[자료 03] 2024-04-02

Generative AI in Azure Data Manager for Agriculture

https://learn.microsoft.com/en-us/azure/data-manager-for-agri/concepts-llm-apis

Microsoft copilot templates empower organizations to build agriculture copilots. Our copilot templates enable seamless retrieval of data stored in Azure Data Manager for Agriculture so that farming-related context and insights can be queried in a conversational context.

Medication management apps that are available on both Android and iOS

Medication management apps that are available on both Android and iOS

Poe’s answer

App NameKey FeaturesUser InterfacePriceNotable Aspects
MedisafeMedication reminders, tracking, refill alertsClean and intuitiveFree (with in-app purchases)Well-known for its user-friendly design and community support
MyTherapyMedication reminders, health tracking, pill diaryIntuitive and user-friendlyFree (with in-app purchases)Supports health tracking alongside medication
Pill Reminder by MedisafeMedication reminders, tracking, refill alertsSimple and effectiveFree (with in-app purchases)Directly similar to Medisafe, familiar UI
CareZoneMedication management, journaling, remindersClean and organizedFree (with in-app purchases)Includes a health journal and photo features
MyMedsMedication reminders, adherence trackingStraightforwardFree (with in-app purchases)Focuses on medication adherence and insights
ScripteasyMedication tracking, reminders, refill alertsModern and cleanFree (with in-app purchases)User-friendly, designed for ease of use

Summary:

  • Medisafe is popular for its comprehensive features and community support.
  • MyTherapy and CareZone are great for those seeking additional health tracking.
  • Pill Reminder by Medisafe offers a familiar interface for Medisafe users.
  • MyMeds is ideal for tracking adherence.
  • Scripteasy focuses on a modern user experience.

Paid plan for Medisafe (Medisafe Premium)

  • monthly: KRW 5,900 on Android, KRW 6,000 on iOS
  • yearly: KRW 44,000 on Android, KRW 49,000 on iOS

Mitch Waldrop on The Dream Machine (2021-08)

Mitch Waldrop on The Dream Machine (2021-08)

by Luminary

Part 1: 1940s-1970s https://luminary.fm/episode/mitch-waldrop-on-the-dream-machine-part-1-1940s-to-1970s/ (2021-08-02)

This first episode touches on Mitch’s journey writing The Dream Machine and the period from the 1940s through the 1970s, which includes: The philosophy underlying hardware and software, the work of intellectual contributors such as Vannevar Bush, Von Nuemann (“Von Neumann”의 오타일 것으로 생각함), and Claude Shannon; interactive computing, the Arpanet, World war II as a catalyst for computing, timesharing, JCR Licklider’s intergalactic network, Arpa’s woodstock moment, and the Xerox Palo Alto Research Center, also known as PARC.

Part 2: 1980s-present https://luminary.fm/episode/mitch-waldrop-on-the-dream-machine-part-2-1980s-to-present/ (2021-08-16)

This second installment of our three-part series with Mitch Waldrop continues from where we left off in episode 1. We launch back into the 70s and make our way through the 80s, 90s, and up to present time. Mitch also offers some thoughts on the future and shares a bit about his recent work.

Part 3: JCR Licklider, Xerox PARC and TCP/IP https://luminary.fm/episode/mitch-waldrop-on-the-dream-machine-part-3-jcr-licklider-xerox-parc-and-tcp-ip/ (2021-08-30)

Our third and final episode with Mitch includes the story behind the intellectual forefather of the internet and interactive computing, JCR Licklider. This was the first recording we did with Mitch which covers a sprawling and wide range of topics, including: JCR Licklider’s role in the research and engineering of personal computing, Xerox PARC and the personal computing revolution, contributions from Alan Turing and Norbert Wiener, adoption of TCP/IP, and the nature of software and computing.

L-Tyrosine

L-Tyrosine

from https://examine.com/supplements/l-tyrosine


amino acid

metabolized to produce catecholamines such as dopamine (DA) and norepinephrine (NE)
taken as a supplement to help increase catecholamine levels depleted during stressful or challenging conditions

used in the production of thyroid hormones

benefits

related to its ability to replenish catecholamine levels in the brain,
which can become depleted under stressful conditions

Multiple studies have demonstrated
that L-tyrosine can help to prevent declined cognitive function under stressful, cognitively demanding conditions

Although it has not been shown to improve memory under resting conditions,
L-tyrosine supplementation has been shown to alleviate reduced memory under acutely stressful conditions.

Overall L-tyrosine appears to be safe and well-tolerated at moderate doses,
with one 2-week human trial using a dose of 2500 mg, provided three times per day,
and another trial using single doses of up to 150 mg/kg of body weight (around 10,000 mg for a 68 kg/150 lb individual),
both with no adverse effects.

drawbacks

Although L-tyrosine has shown beneficial effects in some studies,
it has a mixed track record for efficacy,
with some studies failing to observe positive effects on cognition.

This may be partially explained by the fact that L-tyrosine increases catecholamine synthesis only when catecholamine levels are depleted, limiting efficacy to sufficiently stressful or challenging conditions. Efficacy may also vary in different individuals, as highlighted by one study that found that the effects of L-tyrosine on cognitive function become detrimental with older age.

There are also possible contraindications for L-tyrosine supplementation in people with hyperthyroidism or anyone taking L-dopa or monoamine oxidase inhibitors. If this applies to you, consult with your physician before supplementing with L-tyrosine.

works

used in the body to make the catecholamines dopamine (DA) and norepinephrine (NE),
which can become depleted under stressful or cognitively challenging conditions.

After supplementation,
L-tyrosine levels in the blood peak after one to two hours,
and stay elevated for up to eight hours.

then passes through the blood-brain barrier,
where it is absorbed by brain cells and converted in a series of enzymatic reactions to DA,
which can be converted to NE through the action of another enzyme.

The ability of L-tyrosine to enhance catecholamine synthesis only in neurons that are actively firing
may explain its ability to reverse the effects of neurotransmitter depletion during stress

dosage

tends to be taken in doses of 500–2000 mg
approximately 30–60 minutes before any acute stressor (this tends to be exercise)

Studies in humans showing
most anti-stress promise for acute supplemental L-Tyrosine use a dosage range of 100–150 mg/kg of bodyweight which can be taken 60 minutes before exercise; this is a dosage range of 9–13.5 g for a 200 lb person and 7–10 g for a 150 lb person.

If using higher doses and finding digestive issues,
this may be split into two doses separated by half an hour (30 and 60 minutes prior to acute stress).


공먹젤 익스트림‘이 ‘공먹젤‘에 비해 더 가지고 있는 요소가 L-Tyrosine이어서 궁금해 확인

성분명(관심 성분만)공먹젤 익스트림공먹젤젤
L-arginine1,500mg1,400mg
L-tyrosine400mg
taurine1,000mg1.000mg
zinc3mg3mg
L-theanine200mg

L-theanine은 help reduce stress and anxiety. 100-400mg/day. 여유 있을 때 내용 추가할 수.

Cloud storage services

Cloud storage services

일단 빠르게 대충 적었다. (시간이 허락하면 조금 다듬자.)

현재 유료 사용 중인: Box, MEGA, Proton Drive 등
사용을 해 보긴 한: Skiff Drive, Nextcloud, Dropbox 등

새로이 관심 두는

Internxt

Individual 기준 2TB에 109.99Euro/y, 9.99Euro/m
무료는 1GB
Lifetime 구입이 가능하다. (2TB 이상)

“Internxt for Education”에서 선생과 학생에 50% 할인 가격을 제시.
교육 할인 외 현재 80% 할인 기간 중 — indidual 2TB가 22Euro/y, 2Euro/m이 된다.

“About us”에서

Founded in 2020 by Fran Villalba Segarra, Internxt is a next-generation open-source cloud storage service based in Europe.

매끈.

https://filen.io/ Filen Cloud Dienste UG

Founded early 2020 in Recklinghausen Germany

Pro 3 plan: 2TB 8.99Euro/m, 89.99Euro/y
무료 10GB

기대되는데 어딘가 아직 약간 덜익은 인상.

https://tresorit.com/

Switzerland
Tresorit AG
Franklinstrasse 27.
8050 Zurich

RegNr: CH-300.3.017.920-5
U-ID: CHE-349.825.210

President of the Board of Directors: Tecla Solari

사람들의 평은 좋은 듯하면서도 가격이 높다는 불만

Personal 1TB: 13.99*12USD/m, 11.99*12USD/y

https://www.egnyte.com/

큰 경쟁사들이 자신들의 서비스와 비교 대상으로 삼기에 한 번 둘러 보았다.

https://icedrive.net/ ID Cloud Services LTD

Privacy에 집중하는 회사인 듯하다. UK.

1TB: 7.99USD/m, 71.88(5.99*12)USD/y, 119.76(4.99*24)USD/2y; 3TB: 14.99USD/m, 131.88(10.99*12)USD/y, 215.76(8.99*24)USD/2y
2-year plan도 있다.
Lifetime plan들을 50% 할인 중

Masked email address로는 가입할 수 없다.

Desktop app으로 full-featured portable(!!)을 제공한다.

흥미롭고, 충분히 성숙한 인상.

pCloud

이것도 언급, 비교가 많이 되더라.

PWA, 바람직한Web 등을 생각하다가

PWA, 바람직한Web 등을 생각하다가

AWS와 Azure 공식 문서들에서 PWA에 관한 내용들을 찾고 있었다.

어찌 https://learn.microsoft.com/en-us/microsoft-edge/progressive-web-apps-chromium/ 에 들어갔다가 재미있는 것들을 보았다.

“To find examples of what PWAs can do, see Myth Busting PWAs.”라 하며 아래의 페이지를 소개.

이렇게 시작하여
 

이런 식으로 하나 하나 헛소리를 부수어 간다.

이 사이트를 보니 생각나는 웹사이트가 있어 여기에 적는다.

https://whatpwacando.today

이 사이트를 생각하니 또 생각나는 비슷한 주소의 사이트도.

https://whatwebcando.today

그리고 아래와 같은 페이지 하단에서 https://webwewant.fyi/ 라는 것을 발견.
 

2024 부산국제록페스티벌 Busan International Rock Festival

2024 부산국제록페스티벌 Busan International Rock Festival

https://busanrockfestival.com/
https://twitter.com/busan_rock

부산광역시 주최, (사)부산문화관광축제조직위원회 주관

예매: http://ticket.yes24.com/Perf/49826?Gcode=009_206
3일권: 232,000원
IPRF와 달리 총 판매 티켓 수에 제한이 있어 구입 서둘러야.
셔틀 패키지 상품도 있다.

내게 새로운 fediverse network들 탐색

내게 새로운 fediverse network들 탐색

Movim 계정으로 로긴해 움직움직하다가
https://volpeon.ink/ 이 분을 발견.
이 분이 fediverse로 Sharkey의 (초대로만 사용자를 받는) 한 instance를 사용하고 계신 것을 보고 activitypub 사용 네트웍으로 Sharkey는 어떠한가 궁금해
https://activitypub.software/TransFem-org/Sharkey 에 방문했다가
https://activitypub.software/ 에 가입까지.

mastodon.social이 등록한 email address를 바꾸는 데에 문제를 가지고 있어 정이 떨어졌다.
주 사용 fediverse를 libranet.de로 하려다가 (사용자가 꾸미지 않아도) 기본적으로 더 예쁘게 생긴 놈이 없을까 뒤지던 중.

그런데 Sharkey는 깔끔은 하지만 일본식으로 귀여워서 내 취향에 생김새는 맞지 않아.
Sharkey가 Misskey의 fork라 하니 Misskey를 한 번 보니 Misskey부터 기본적으로 그런 분위기.
여긴 접자.

저것보다가 이런저런 이유로 짜근넷이 기억났.

Havana Syndrome

Havana Syndrome

BBC Radio 4 – Crossing Continents: The Mystery of Havana Syndrome

(article) “Havana Syndrome: The History Behind the Mystery”

2024-04-01 https://www.fpri.org/article/2024/04/havana-syndrome-the-history-behind-the-mystery/

  • Possibly up to 1,500 American officials at home and abroad have suffered brain and other injuries in recent years from a mysterious malady that is reported to have begun in Havana in 2016 and has since been known as Havana Syndrome.
  • While aspects of these health incidents remain a mystery, they recall a series of historically documented Soviet technical operations against the US embassy in Moscow that began in 1953 and lasted for decades, providing credible evidence of serious harm to numerous diplomats and other US officials.
  • Since the fall of the Soviet Union, President Vladimir Putin and Russian military officers have publicly bragged about developing weapons that could cause health effects similar to Havana Syndrome.
    After attacks on officials of successive administrations, CIA Director William Burns may finally have put an end to such incidents by threatening the Russians with retaliation.
  • But the policy of tolerating, denying, and concealing decades of Russian attacks, at the expense of American officials, has harmed the credibility and weakened the power of the US government to deter other acts of aggression.

(article) “Unraveling Havana Syndrome: New evidence links the GRU’s assassination Unit 29155 to mysterious attacks on U.S. officials and their families”

2024-04-01 https://theins.ru/en/politics/270425

A yearlong investigation by The Insider, in collaboration with 60 Minutes and Der Spiegel, has uncovered evidence suggesting that unexplained anomalous health incidents, also known as Havana Syndrome, may have their origin in the use of directed energy weapons wielded by members of Russian GRU Unit 29155. Members of the Kremlin’s infamous military intelligence sabotage squad have been placed at the scene of suspected attacks on overseas U.S. government personnel and their family members, leading victims to question what Washington knows about the origins of Havana Syndrome, and what an appropriate Western response might entail.

(article) “CIA doctor hit by Havana syndrome says he was in ‘disbelief’ as he suffered what he was investigating”

2022-09-25 https://edition.cnn.com/2022/09/25/politics/havana-syndrome-cia-doctor-cnn-special/index.html

CIA physician Dr. Paul Andrews was one of the first people sent to Havana, Cuba, to investigate a spate of mysterious health incidents that were impacting embassy and agency personnel in 2017 when he was struck by the same set of debilitating symptoms, he told CNN Chief Medical Correspondent Dr. Sanjay Gupta in his first public interview for a CNN Special Report: “Immaculate Concussion: The Truth About Havana Syndrome.”

(article) “A ‘Havana Syndrome’ Investigation in Congress Rest on Politics, Not Science”

2024-03-15 https://www.scientificamerican.com/article/a-havana-syndrome-investigation-in-congress-rests-on-politics-not-science/

Lawmakers should look in the mirror if they want answers to who hyped dubious reports of Havana syndrome. Instead they are investigating the spy agencies telling them the truth about the mystery

Law & Order S21 E08 “Severance”

https://www.imdb.com/title/tt19712404/

aired on 2022-05-05

based on several real world cases/incidents besides “Havana syndrome” phenomenon:

  • Tesla, Inc. workplace controversies (2020)
  • The “Facebook Files” leak involving Frances Haugen (2021)
  • The murder of Tracie McBride by Louis Jones Jr. and the related controversial Gulf War syndrome clemency defence

※ Chronic traumatic encephalopathy (CTE, 만성 외상성 뇌병)

A neurodegenerative disease linked to repeated trauma to the head.

Symptoms occur in four stages and typically manifest 8 to 10 years after an individual experiences repetitive mild traumatic brain injuries.

  • Stage 1: confusion, disorientation, dizziness, headaches
  • Stage 2: memory loss, social instability, impulsive behaviour, poor judgment
  • Stage 3 and 4: impediments, sensory processing disorder, tremors, vertigo, deafness, depression, suicidality

A definitive diagnosis of CTE can only be made during an autopsy, as it cannot be confirmed in living individuals. While some researchers link certain signs and symptoms to CTE, no conclusive test exists to identify it in living people. Additionally, the signs often resemble those of other neurological conditions like Alzheimer’s.

https://en.wikipedia.org/wiki/Chronic_traumatic_encephalopathy

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