I experience severe discomfort without any specific diagnosed diseases or injuries. When I take 6g of arginine jelly and a 200mg caffeine caplet, I feel completely fine after about 30 minutes. Does this make sense, or could it just be a placebo effect?
ChatGPT’s answer is:
This reaction can indeed make sense, as both L-arginine and caffeine can have physiological effects that might temporarily alleviate feelings of discomfort or low energy.
L-arginine Effects: Arginine is an amino acid that helps increase nitric oxide production, which can improve blood flow and enhance oxygen delivery to tissues. This process can lead to feelings of improved energy or reduced fatigue, which may contribute to your overall sense of relief.
Caffeine Effects: Caffeine is a central nervous system stimulant that can improve alertness, reduce perceived fatigue, and elevate mood temporarily. The 200mg dose is considered moderate and can boost energy levels, often providing relief if discomfort is related to low energy or mental fog.
Placebo Factor: While these effects are likely real and based on the substances’ mechanisms, the placebo effect could still play a role, especially if your body has come to expect relief from this combination. The mere anticipation of feeling better can amplify the effects, making the combination feel even more effective.
In summary, it’s plausible that both physiological effects and placebo may be contributing to the relief you experience.
New connectors allow secure, compliant data exchange / Industry platform Microsoft Azure Data Manager expands as more companies bring solutions: Leaf Agriculture further enhances useability of farm machinery data and OneSoil powers in-season detection and identification of key cash crops / Bayer experts are available from November 12-18 in hall 8, booth C15
Bayer and Microsoft have announced new data connectors that enable secure and compliant data exchange between Bayer’s digital farming platform, Climate FieldView™, and original equipment manufacturers (OEMs) via Microsoft’s Azure Data Manager for Agriculture. This collaboration aims to address the longstanding issue of data interoperability in agriculture, allowing farmers to seamlessly integrate and utilize data from various sources. By enhancing connectivity, the partnership seeks to improve decision-making processes, promote sustainable practices, and drive innovation across the agricultural value chain.
Microsoft is focusing on empowering around 600 million smallholder farmers globally by offering access to essential technology solutions.
Through Azure Data Manager for Agriculture and generative AI, Microsoft aims to help farmers implement smarter, sustainable farming practices.
The article highlights key challenges farmers face:
Yield losses can reach up to 40% due to pests and diseases.
Limited access to critical information and agronomic expertise, as seen in India, where agriculture employs over 43% of the workforce.
Microsoft collaborates with partners like ITC (an Indian multi-business company) to develop Krishi Mitra (“farming friend”):
An agricultural super app based on Microsoft’s copilot template.
Allows farmers to ask questions in their native languages, with AI-powered responses on weather, agronomy, and other key topics.
The app integrates natural language chat functionality with generative AI to provide tailored guidance on:
Crop management
Pest control
Soil health
Water conservation
Microsoft’s language localization tools ensure the app serves a linguistically diverse user base, giving farmers critical farming information in their preferred languages.
Expansion Goals:
By the end of 2024: Reach over 100,000 farmers in India.
By 2030: Aim for a 10 million user base, enhancing agricultural decision-making and sustainable practices.
[자료 03] 2024-04-02
Generative AI in Azure Data Manager for Agriculture
Microsoft copilot templates empower organizations to build agriculture copilots. Our copilot templates enable seamless retrieval of data stored in Azure Data Manager for Agriculture so that farming-related context and insights can be queried in a conversational context.
This first episode touches on Mitch’s journey writing The Dream Machine and the period from the 1940s through the 1970s, which includes: The philosophy underlying hardware and software, the work of intellectual contributors such as Vannevar Bush, Von Nuemann (“Von Neumann”의 오타일 것으로 생각함), and Claude Shannon; interactive computing, the Arpanet, World war II as a catalyst for computing, timesharing, JCR Licklider’s intergalactic network, Arpa’s woodstock moment, and the Xerox Palo Alto Research Center, also known as PARC.
This second installment of our three-part series with Mitch Waldrop continues from where we left off in episode 1. We launch back into the 70s and make our way through the 80s, 90s, and up to present time. Mitch also offers some thoughts on the future and shares a bit about his recent work.
Our third and final episode with Mitch includes the story behind the intellectual forefather of the internet and interactive computing, JCR Licklider. This was the first recording we did with Mitch which covers a sprawling and wide range of topics, including: JCR Licklider’s role in the research and engineering of personal computing, Xerox PARC and the personal computing revolution, contributions from Alan Turing and Norbert Wiener, adoption of TCP/IP, and the nature of software and computing.
metabolized to produce catecholamines such as dopamine (DA) and norepinephrine (NE) taken as a supplement to help increase catecholamine levels depleted during stressful or challenging conditions
used in the production of thyroid hormones
benefits
related to its ability to replenish catecholamine levels in the brain, which can become depleted under stressful conditions
Multiple studies have demonstrated that L-tyrosine can help to prevent declined cognitive function under stressful, cognitively demanding conditions
Although it has not been shown to improve memory under resting conditions, L-tyrosine supplementation has been shown to alleviate reduced memory under acutely stressful conditions.
Overall L-tyrosine appears to be safe and well-tolerated at moderate doses, with one 2-week human trial using a dose of 2500 mg, provided three times per day, and another trial using single doses of up to 150 mg/kg of body weight (around 10,000 mg for a 68 kg/150 lb individual), both with no adverse effects.
drawbacks
Although L-tyrosine has shown beneficial effects in some studies, it has a mixed track record for efficacy, with some studies failing to observe positive effects on cognition.
This may be partially explained by the fact that L-tyrosine increases catecholamine synthesis only when catecholamine levels are depleted, limiting efficacy to sufficiently stressful or challenging conditions. Efficacy may also vary in different individuals, as highlighted by one study that found that the effects of L-tyrosine on cognitive function become detrimental with older age.
There are also possible contraindications for L-tyrosine supplementation in people with hyperthyroidism or anyone taking L-dopa or monoamine oxidase inhibitors. If this applies to you, consult with your physician before supplementing with L-tyrosine.
works
used in the body to make the catecholamines dopamine (DA) and norepinephrine (NE), which can become depleted under stressful or cognitively challenging conditions.
After supplementation, L-tyrosine levels in the blood peak after one to two hours, and stay elevated for up to eight hours.
then passes through the blood-brain barrier, where it is absorbed by brain cells and converted in a series of enzymatic reactions to DA, which can be converted to NE through the action of another enzyme.
The ability of L-tyrosine to enhance catecholamine synthesis only in neurons that are actively firing may explain its ability to reverse the effects of neurotransmitter depletion during stress
dosage
tends to be taken in doses of 500–2000 mg approximately 30–60 minutes before any acute stressor (this tends to be exercise)
Studies in humans showing most anti-stress promise for acute supplemental L-Tyrosine use a dosage range of 100–150 mg/kg of bodyweight which can be taken 60 minutes before exercise; this is a dosage range of 9–13.5 g for a 200 lb person and 7–10 g for a 150 lb person.
If using higher doses and finding digestive issues, this may be split into two doses separated by half an hour (30 and 60 minutes prior to acute stress).
‘공먹젤 익스트림‘이 ‘공먹젤‘에 비해 더 가지고 있는 요소가 L-Tyrosine이어서 궁금해 확인
Possibly up to 1,500 American officials at home and abroad have suffered brain and other injuries in recent years from a mysterious malady that is reported to have begun in Havana in 2016 and has since been known as Havana Syndrome.
While aspects of these health incidents remain a mystery, they recall a series of historically documented Soviet technical operations against the US embassy in Moscow that began in 1953 and lasted for decades, providing credible evidence of serious harm to numerous diplomats and other US officials.
Since the fall of the Soviet Union, President Vladimir Putin and Russian military officers have publicly bragged about developing weapons that could cause health effects similar to Havana Syndrome. After attacks on officials of successive administrations, CIA Director William Burns may finally have put an end to such incidents by threatening the Russians with retaliation.
But the policy of tolerating, denying, and concealing decades of Russian attacks, at the expense of American officials, has harmed the credibility and weakened the power of the US government to deter other acts of aggression.
(article) “Unraveling Havana Syndrome: New evidence links the GRU’s assassination Unit 29155 to mysterious attacks on U.S. officials and their families”
A yearlong investigation by The Insider, in collaboration with 60 Minutes and Der Spiegel, has uncovered evidence suggesting that unexplained anomalous health incidents, also known as Havana Syndrome, may have their origin in the use of directed energy weapons wielded by members of Russian GRU Unit 29155. Members of the Kremlin’s infamous military intelligence sabotage squad have been placed at the scene of suspected attacks on overseas U.S. government personnel and their family members, leading victims to question what Washington knows about the origins of Havana Syndrome, and what an appropriate Western response might entail.
(article) “CIA doctor hit by Havana syndrome says he was in ‘disbelief’ as he suffered what he was investigating”
CIA physician Dr. Paul Andrews was one of the first people sent to Havana, Cuba, to investigate a spate of mysterious health incidents that were impacting embassy and agency personnel in 2017 when he was struck by the same set of debilitating symptoms, he told CNN Chief Medical Correspondent Dr. Sanjay Gupta in his first public interview for a CNN Special Report: “Immaculate Concussion: The Truth About Havana Syndrome.”
(article) “A ‘Havana Syndrome’ Investigation in Congress Rest on Politics, Not Science”
Lawmakers should look in the mirror if they want answers to who hyped dubious reports of Havana syndrome. Instead they are investigating the spy agencies telling them the truth about the mystery
A definitive diagnosis of CTE can only be made during an autopsy, as it cannot be confirmed in living individuals. While some researchers link certain signs and symptoms to CTE, no conclusive test exists to identify it in living people. Additionally, the signs often resemble those of other neurological conditions like Alzheimer’s.
